Thursday, September 20, 2012

September 25, 2012 journal club

  • When:  Tuesday, Sept. 25, 12:15 PM  
  • Where:  Room E6519
And we're back! -- from the summer hiatus that is.  
Kate Laws of the Drummond-Barbosa lab will be presenting a paper, hot off the presses in Nature:  

RPN-6 determines C. elegans longevity under proteotoxic stress conditions 
Nature 489:263-268
Vilchez et al

Dillin lab page at Salk        Dillin lab personal page

Kate's comments on why she chose this paper (just in case you're looking at the title and thinking, "What a minute, what does this have to do with reproduction?") ...

"Previous studies discussed in this very journal club have noted the inverse correlation between an organism's reproductive capacity and its lifespan, with a lot of attention granted to insulin and insulin-like signaling pathways (which I probably don't need to mention is of particular interest to our lab).  Here, the authors set their sights on another pathway that they hypothesize could contribute to longevity: the ubiquitin proteasome system.  By employing germline-ablated animals, the investigators are able to probe the implications of partitioned resources have on longevity...pretty neat!"  

Thus, broad relevance of this paper with multiple interests in the RBJC group and BMB department!  All welcome!