- When: Tuesday, Nov. 6, 12:15 PM
- Where: Room W4019
- W4019 is a small classroom on the eastern side of the SPH building (couldn't get E6519 for all of our meetings)
Lauren Matthews (Evans lab) will be presenting:
MARF1 Regulates Essential Oogenic Processes in Mice
Su et al., Science (2012) 335:1496-1499
Lauren's comments on her paper choice:
"This paper characterizes an interesting mutant from the Jackson Lab's Reproductive Genomics project. Mutations in Marf1 (Meiotic arrest female 1) resulted in defects in oocyte meiotic maturation and female infertility. I chose this paper because one of the defects seen in Marf1 mutant mice was the upregulation of protein phosphatase 2 catalytic subunit (PPP2CB). Increased PP2 activity contributes to the meiotic maturation defect seen Marf1 mutant mice. One of the goals of my thesis research project is to characterize a novel pathway regulating PP2A function in mouse oocytes, so I read this paper with great interest!"